|
KMID : 0388220080150020118
|
|
Journal of the Korean Rheumatism Association
2008 Volume.15 No. 2 p.118 ~ p.122
|
|
|
Increased Interleukin-17 Expression in Patients with Idiopathic Inflammatory Myopathies
|
|
Baek Seung-Hoon
Lee Jun-Hee
Lee Joung-Wook
Cho Mi-La
Kim Seong-Il
Kim Joo-In
Kim Dae-Seong
Lee Sun-Hee
Kim Geun-Tae
|
|
|
Abstract
|
|
|
Objective:Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by infiltration of T lymphocytes, monocytes, and macrophages in muscle tissues. Interleukin-17 (IL-17), a Th17 cytokine, has potent pro-inflammatory actions and plays a role in autoimmune diseases. We investigated the expression of IL-17 in muscle tissues of patients with IIMs.
Methods: We measured the IL-17 mRNA level of muscle tissues from 14 patients with IIMs (9 patients with dermatomyositis and 5 patients with polymyositis) by real-time RT-PCR and compared with controls. We also performed an immunohistochemical stain to detect IL-17 expression.
Results:The expressions of IL-17 were significantly enhanced in IIMs than controls. In immunohistochemistry, IL-17 was expressed in perimysial, endomysial and perivascular infiltrating inflammatory cells.
Conclusion:These results suggest that IL-17 plays a role in the immunopathogenesis of IIMs.
|
|
|
KEYWORD
|
|
|
Interleukin-17, Idiopathic inflammatory myopathies, Dermatomyositis, Polymyositis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|